Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder. Inespecfic disfunciones irregularidad os edema congnitas. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. Fisiopatologia del lupus eritematoso sistemico elsevier. Lupus erythematosus le is a chronic autoimmune disease which involves connective tissue. The journals aim is to improve knowledge among rheumatologists and to stimulate research through the publication of all original contributions in rheumatology in spanish and english. Abstract systemic lupus erythematosus is the paradigm of systemic autoimmune syndrome, whose etiology is far from being clarified, although the knowledge of its pathogenesis has inexorably advanced in recent years, such as the most hidden secrets of the. Citescore values are based on citation counts in a given year e. Dendritic cells and interferons in systemic lupus erythematosus.
Systemic lupus erythematosus sle is an autoimmune disorder with a genetic basis, and is characterized by the appearance of autoantibodies, the formation and deposition of circulating immune complexes, and chronic inflammation in various organs. Ultraviolet radiation is the environmental factor most linked to lupus, and causes exacerbation in 70% of patients to increase apoptosis of keratinocytes and other cells or by altering the dna and intracellular proteins so they become antigenic. Although le manifestations are diverse, the disease has been classificated into two forms. It has a female predilection during the reproductive period. This is an open access article under the cc byncnd license. Abstract systemic lupus erythematosus is the paradigm of systemic autoimmune syndrome, whose etiologyis farfrom being clarified, although the knowledge of its pathogenesis has inexorably advanced in recent years, such as the most hidden secrets of the functioning of the. Goldmans cecil medicine, 24th edition expert consult.
Manifestaciones bucales en pacientes con lupus eritematoso. Systemic lupus erythematosus sle is a chronic, autoimmune inflammatory disease that. Escrerosis multiple, lupus eritematoso lupus eritematoso. Effect of vitamin d supplementation on patients with systemic lupus. Volume 57, issue 5, septemberoctober 2017, pages 466471.
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